Dave's PCF WIP: Terms

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continuous refreshed perfusate

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"Continuous Refreshed Perfusate" refers to a quantity of perfusate that is refreshed from a suboptimal state to a more optimal state without interrupting, disrupting, or stopping fluid flow within a perfusion circuit. As used herein, continuous refers to a process with no break or interruption, as well as a process with a nominal break or interruption, as well as a process with a break or interruption that is small or short enough that one or more perfused organ experiences nominal or no adverse effects from the break or interruption. Those of skill in the art will appreciate that the perfusate can be refreshed using a variety of methods, processes, techniques, devices, structures, systems, apparatuses, and the like. For example, the perfusate can be refreshed by way of one or more inline filters, a hemofiltration process (conducting using mechanical devices and/or living organs), a bulk perfusate exchange process, a constant perfusate replacement process, a dialysis process, a blood gas exchange process, a pH adjustment process, a temperature adjustment process, an oncotic pressure adjustment process, an addition of one or more nutrients, an addition of one or more additives, an addition of one or more supplements, an addition of one or more drugs, or the like.