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As used herein, a “long bone” refers to a bone of a patient having a length greater than a width of the bone. Long bone is one of five types of bones: long, short, flat, irregular and sesamoid. Long bones, especially the femur and tibia, can be subjected to most of the load during daily activities. Long bones grow primarily by elongation of the diaphysis, with an epiphysis at each end of the growing bone. The ends of epiphyses are covered with hyaline cartilage ("articular cartilage"). The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. The long bone category type includes the femur, tibia, and fibula of the legs; the humerus, radius, and ulna of the arms; metacarpals and metatarsals of the hands and feet, the phalanges of the fingers and toes, and the clavicles or collar bones in humans or other patients. The outside of the long bone consists of a layer of connective tissue called the periosteum. Additionally, the outer shell of the long bone is compact bone, then a deeper layer of cancellous bone (spongy bone) which includes a medullary cavity that includes bone marrow. (Search "long bone" on Wikipedia.com May 14, 2021. CC-BY-SA 3.0 Modified. Accessed July 26, 2021.)

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<w:p w14:paraId="62403E68" w14:textId="46EC7CB7" w:rsidR="00535B04" w:rsidRPr="000849B1" w:rsidRDefault="007812E9" w:rsidP="007812E9"><w:pPr><w:pStyle w:val="NumberedParagraph"/></w:pPr><w:r w:rsidRPr="000849B1"><w:t xml:space="preserve">As used herein, a “long bone” refers to a bone of a patient having a length </w:t></w:r><w:r w:rsidR="00110C69" w:rsidRPr="000849B1"><w:t>greater</w:t></w:r><w:r w:rsidRPr="000849B1"><w:t xml:space="preserve"> than a width of the bone. Long bone is one of five types of bones: long, short, flat, irregular and </w:t></w:r><w:r w:rsidRPr="000849B1"><w:lastRenderedPageBreak/><w:t xml:space="preserve">sesamoid. Long bones, especially the </w:t></w:r><w:bookmarkStart w:id="1576" w:name="CMASTER8716687171"/><w:r w:rsidRPr="000849B1"><w:t>femur</w:t></w:r><w:bookmarkEnd w:id="1576"/><w:r w:rsidRPr="000849B1"><w:t xml:space="preserve"> and tibia, can be subjected to most of the load during daily activities. Long bones grow primarily by elongation of the diaphysis, with an epiphysis at each end of the growing bone. The ends of epiphyses are covered with hyaline cartilage ("articular cartilage"). The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. The long bone category type includes the </w:t></w:r><w:bookmarkStart w:id="1577" w:name="CMASTER8758187586"/><w:r w:rsidRPr="000849B1"><w:t>femur</w:t></w:r><w:bookmarkEnd w:id="1577"/><w:r w:rsidRPr="000849B1"><w:t xml:space="preserve">, tibia, and fibula of the legs; the humerus, radius, and ulna of the </w:t></w:r><w:bookmarkStart w:id="1578" w:name="CMASTER8765687659"/><w:bookmarkStart w:id="1579" w:name="CMASTER8765687660"/><w:r w:rsidRPr="000849B1"><w:t>arm</w:t></w:r><w:bookmarkEnd w:id="1578"/><w:r w:rsidRPr="000849B1"><w:t>s</w:t></w:r><w:bookmarkEnd w:id="1579"/><w:r w:rsidRPr="000849B1"><w:t>; metacarpals and metatarsals of the hands and feet, the phalanges of the fingers and toes, and the clavicles or collar bones in humans or other patients. The outside of the long bone consists of a layer of connective tissue called the periosteum. Additionally, the outer shell of the long bone is compact bone, then a deeper layer of cancellous bone (spongy bone) which includes a medullary cavity that includes bone marrow. (Search "long bone" on Wikipedia.com May 14, 2021. CC-BY-SA 3.0 Modified. Accessed July 26, 2021.)</w:t></w:r></w:p>