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Alternatively, or in addition, in certain embodiments, one or both of, the first resection feature and second resection feature may be positioned on, or in, the body 610 and/or have an orientation based on patient imaging data. The patient imaging data can be used to position and orient one, or both, of the first resection feature and second resection feature such that formation of one, or both, of the first cut surface and the second cut surface and fixation of the two cut surfaces against each other mitigates a condition of the patient. For example, as described in the present disclosure, patient imaging data can be used to generate bone models of bones of the patient. The bone models can be used to determine and/or define contours for a bone engagement surface 624, a position for a first slot 660, an orientation for a first slot 660, a position for a second slot 670, an orientation for a second slot 670, as well as other features and attributes of one or more patient specific instruments that can be used in a procedure.

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