{
    "matter": "US20140066758",
    "document_type": "Patent terminology definitions",
    "definitions": [
        {
            "term": "biologic",
            "definition": "\"Biologic\" refers to at least one bone growth material to promote bone growth in a surgical site or a location adjacent a surgical site. The bone growth material may include solid materials, such as, for example, bone graft, allograft chips, autogenous morselized bone graft, strips of autogenous bone graft, demineralized bone matrix in powder, paste, putty, gel, strip, or other forms, xenografts and fired bone. The solids can also be bone graft substitutes, such as hydroxyapatite, calcium carbonate, beta tricalcium phosphate, calcium sulfate or mineralized collagen, natural or synthetic polymers such as collagen particles, meshes, sponges, and gels, hyaluronic acid and derivatives thereof, liposomes or other natural biomaterials known as potential implants, or carriers of therapeutic agents, such as cytokines, growth factors, cells, antibiotics, analgesics, chemotherapeutic drugs, and the like. The bone growth material may include synthetic polymers, such as, for example, alpha-hydroxy polyesters, including polylactic acid, polyglycolic acid and their copolymers, polydioxanone, as well as poly methyl methacrylate, separately, in mixture or in admixture with any of the therapeutic agents described.\r\n\r\nThe bone growth material(s) used may include a therapeutically effective amount of a growth factor including, for example, osteoinductive agents (e.g. agents that cause new bone growth in an area where there was none before) and/or osteoconductive agents (e.g. agents that cause ingrowth of cells into and/or through the matrix). Osteoinductive agents can be polypeptides or polynucleotides compositions. Polynucleotide compositions of the osteoinductive agents include, but are not limited to, isolated Bone Morphogenic Protein (BMP), Vascular Endothelial Growth Factor (VEGF), Connective Tissue Growth Factor (CTGF), Osteoprotegerin, Growth Differentiation Factors (GDFs), Cartilage Derived Morphogenic Proteins (CDMPs), Lim Mineralization Proteins (LMPs), Platelet derived growth factor, (PDGF or rhPDGF), Insulin-like growth factor (IGF) or Transforming Growth Factor beta (TGF-beta) polynucleotides. Polynucleotide compositions of the osteoinductive agents include, but are not limited to, gene therapy vectors harboring polynucleotides encoding the osteoinductive polypeptide of interest. Gene therapy methods often utilize a polynucleotide, which codes for the osteoinductive polypeptide operatively linked or associated to a promoter or any other genetic elements necessary for the expression of the osteoinductive polypeptide by the target tissue. Suitable gene therapy vectors include, but are not limited to, gene therapy vectors that do not integrate into the host genome. Other suitable gene therapy vectors include, but are not limited to, gene therapy vectors that integrate into the host genome."
        },
        {
            "term": "growth factor",
            "definition": "\"Growth factor\" refers to for example, osteoinductive agents (e.g. agents that cause new bone growth in an area where there was none before) and/or osteoconductive agents (e.g. agents that cause ingrowth of cells into and/or through the matrix). Osteoinductive agents can be polypeptides or polynucleotides compositions. Polynucleotide compositions of the osteoinductive agents include, but are not limited to, isolated Bone Morphogenic Protein (BMP), Vascular Endothelial Growth Factor (VEGF), Connective Tissue Growth Factor (CTGF), Osteoprotegerin, Growth Differentiation Factors (GDFs), Cartilage Derived Morphogenic Proteins (CDMPs), Lim Mineralization Proteins (LMPs), Platelet derived growth factor, (PDGF or rhPDGF), Insulin-like growth factor (IGF) or Transforming Growth Factor beta (TGF-beta) polynucleotides. Polynucleotide compositions of the osteoinductive agents include, but are not limited to, gene therapy vectors harboring polynucleotides encoding the osteoinductive polypeptide of interest. Gene therapy methods often utilize a polynucleotide, which codes for the osteoinductive polypeptide operatively linked or associated to a promoter or any other genetic elements necessary for the expression of the osteoinductive polypeptide by the target tissue. Suitable gene therapy vectors include, but are not limited to, gene therapy vectors that do not integrate into the host genome. Other suitable gene therapy vectors include, but are not limited to, gene therapy vectors that integrate into the host genome."
        }
    ]
}